After reviewing the top 15 hot flash and night sweat supplements, our favorite by far was Thermella by Bonafide. Bonafide is a leading company in the Women’s health supplement industry, known for their rigorous clinical studies, doctor recommended products, quality ingredients, exceptional customer service, and outstanding products.

Their hot flash and night sweat supplement is no exception. Thermella by Bonafide is a top-tier product for managing hot flashes and night sweats, backed by both clinical trials and glowing user reviews.

Its patented, clinically tested formulation specifically targets the root cause of hot flashes—neurokinin B (NKB)—by rebalancing the body’s thermoregulatory center, providing fast relief.

Many women report significant improvements within just two weeks of use. As the first non-prescription treatment to address hot flashes at their source, Bonafide as a company is recommended by over 17,000 uncompensated healthcare providers, reflecting its reliability.

Although it comes with a premium price tag, its long-term effectiveness and the rigorous safety testing it undergoes make it a worthwhile investment for those seeking real relief from menopause symptoms.

Relizen has been trusted by over 1 million women for more than 15 years, offering hormone-free relief from menopausal hot flashes and night sweats. It is clinically studied and widely recommended by thousands of doctors. While effective, Relizen works gradually, with most users reporting significant improvement by the third month. With Bonafide’s introduction of Thermella—a faster-acting, non-prescription treatment that targets hot flashes at the source—it’s likely that Thermella will replace Relizen in the near future.

While Amberen claims to address a wide range of menopause symptoms with just one supplement, this can understandably raise skepticism. Despite positive results reported by many women, the product contains a relatively long list of inactive ingredients—including Gelatin, Rice Flour, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, Riboflavin, and Carmine—which provide no health benefits and may potentially interfere with the active ingredients effectiveness.

However, the deal breaker for us is that their product has not gained the trust of the healthcare community. Additionally, Amberen is backed by only a single 12-week study from 2016 (after FTC misleading claims complaint in 2015), which doesn’t compare to our top pick—which has multiple clinical studies supporting its effectiveness. For these reasons, Amberen falls behind our top choices, including the winner, Thermella.

Estroven makes bold claims about relieving multiple menopause symptoms, but their clever use of the word "clinical" is misleading. While the main ingredient of rhapontic rhubarb has been shown to alleviate certain symptoms in clinical studies, the product's specific formulation has not undergone clinical testing.

This lack of rigorous evaluation means it's not widely recommended by the healthcare community. At first glance, the product may seem clinically tested, but upon deeper review, it falls short compared to our top-rated option, Thermella, which is clinically proven and trusted by medical professionals.Another concern for us is the use of long term efficacy which many women reported that the product stopped working with prolonged use.

The last deal breaker for us was, like Amberven, this product contains a relatively long list of inactive ingredients—including Dicalcium Phosphate, Microcrystalline Cellulose, Coating [titanium dioxide [color], sodium alginate, maltodextrin and the list goes on—which provide no health benefits and may potentially interfere with the active ingredients' effectiveness.

O Positive’s menopause relief product is visually well-marketed and popular on platforms like TikTok, but its claims of clinical effectiveness are misleading. The specific formulation hasn't undergone clinical testing, and while some users report relief, many complain of poor results and quality control issues.

Like most supplements, the lack of clinical validation and inconsistent absorption rates raises concerns. Compared to top options like Thermella, which is clinically studied and trusted by healthcare professionals, O Positive’s product falls short.